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Title: Characterization and function of two G-protein regulators, vertebrate LGN and Drosophila RapGAP
Keywords: LGN, G-protein, cell cortex, primary motor neuron, RapGAP, dbd lineage
Issue Date: 17-Sep-2004
Citation: RACHNA KAUSHIK (2004-09-17). Characterization and function of two G-protein regulators, vertebrate LGN and Drosophila RapGAP. ScholarBank@NUS Repository.
Abstract: Mammalian LGN/AGS3 proteins and their Drosophila Pins orthologue are cytoplasmic regulators of G-protein signaling in the cell. This thesis provides evidence for a novel localization of LGN during cell cycle progression and also characterizes functions of vertebrate LGN homologues from mouse and zebrafish using mammalian cell culture systems and zebrafish as model systems respectively. I show here that LGN is required mitotically in cell cycle progression and post-mitotically in primary motor neuron formation. In addition, I have characterized another G-protein regulatory protein, DRapGAP2 from Drosophila and shown that it is required for dbd neuron formation during embryonic PNS development in Drosophila.
Appears in Collections:Ph.D Theses (Open)

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