Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/13959
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dc.titleThe small GTPASE - ARF like protein 1 (ARL1) is a new regulator of golgi structure and function
dc.contributor.authorLU LEI
dc.date.accessioned2010-04-08T10:38:29Z
dc.date.available2010-04-08T10:38:29Z
dc.date.issued2004-05-31
dc.identifier.citationLU LEI (2004-05-31). The small GTPASE - ARF like protein 1 (ARL1) is a new regulator of golgi structure and function. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/13959
dc.description.abstractArl1 (ARF like protein1) is a poorly understood member of ARF family small GTPases. This thesis presents an original characterization of Arl1 and its effectors. Arl1 was localized to the tans Golgi under EM. Over expression of guanine nucleotide mutants of Arl1 dramatically affects the structure and function of Golgi apparatus. Arl1-GTP was found to interact with GRIP domain of Golgins (Golgin-97, Golgin-245, GCC1 and KIAA0336). The interaction was dependent on the conserved amino acids on both switch II region of Arl1 and the GRIP domain. Collectively, the research presented in this thesis reveals Arl1 is a new regulator of Golgi structure and function and one mechanism of Arl1a??s function is that it recruits and regulates its effectors a?? GRIP domain Golgins to Golgi.
dc.language.isoen
dc.subjectsmall GTPase, ARF1, Arl1, Golgi, GRIP domain Golgin, protein trafficking
dc.typeThesis
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.contributor.supervisorHONG WAN JIN
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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