Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/138904
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dc.titleNOVEL MITOCHONDRIA - TARGETING ANTICANCER PLATINUM (IV) COMPLEXES: SYNTHESIS, CHARACTERIZATION, AND MECHANISMS OF ACTION
dc.contributor.authorYANG ZHI
dc.date.accessioned2018-02-15T18:00:15Z
dc.date.available2018-02-15T18:00:15Z
dc.date.issued2017-09-27
dc.identifier.citationYANG ZHI (2017-09-27). NOVEL MITOCHONDRIA - TARGETING ANTICANCER PLATINUM (IV) COMPLEXES: SYNTHESIS, CHARACTERIZATION, AND MECHANISMS OF ACTION. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/138904
dc.description.abstractPlatinum(IV) compounds provide an opportunity to overcome some of these limitations. Within a large variety of platinum(IV) complexes that have been synthesized to date, only four candidates have made it into clinical trials and unluckily none of them showed a supreme anticancer efficacy over conventional platinum(II) drugs. One possible reason for these failures is that almost all platinum(IV) compounds are focused on the interaction between platinum atom and nuclear DNA to cause nuclear DNA damage, which is likely to be fixed by the inherent DNA damage repair system of cancer cells. Few researchers have focused their attention to the effect of platinum(IV) compounds on mitochondria, specifically mitochondrial DNA. As the cellular power supplier, mitochondria have their own DNA that could also be the potential target for platinum(IV) compounds. More importantly, mitochondrial DNA lacks its own repair mechanism and is more susceptible to the influence of the mitochondrial respiratory function.
dc.language.isoen
dc.subjectAnticancer, Platinum, ROS, Mitochondria, Mechanisms, Drug delivery
dc.typeThesis
dc.contributor.departmentPHARMACY
dc.contributor.supervisorPASTORIN, GIORGIA
dc.contributor.supervisorDAN GIBSON
dc.description.degreePh.D
dc.description.degreeconferredNUS-HUJ JOINT PH.D.
Appears in Collections:Ph.D Theses (Open)

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