Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/138904
Title: NOVEL MITOCHONDRIA - TARGETING ANTICANCER PLATINUM (IV) COMPLEXES: SYNTHESIS, CHARACTERIZATION, AND MECHANISMS OF ACTION
Authors: YANG ZHI
Keywords: Anticancer, Platinum, ROS, Mitochondria, Mechanisms, Drug delivery
Issue Date: 27-Sep-2017
Citation: YANG ZHI (2017-09-27). NOVEL MITOCHONDRIA - TARGETING ANTICANCER PLATINUM (IV) COMPLEXES: SYNTHESIS, CHARACTERIZATION, AND MECHANISMS OF ACTION. ScholarBank@NUS Repository.
Abstract: Platinum(IV) compounds provide an opportunity to overcome some of these limitations. Within a large variety of platinum(IV) complexes that have been synthesized to date, only four candidates have made it into clinical trials and unluckily none of them showed a supreme anticancer efficacy over conventional platinum(II) drugs. One possible reason for these failures is that almost all platinum(IV) compounds are focused on the interaction between platinum atom and nuclear DNA to cause nuclear DNA damage, which is likely to be fixed by the inherent DNA damage repair system of cancer cells. Few researchers have focused their attention to the effect of platinum(IV) compounds on mitochondria, specifically mitochondrial DNA. As the cellular power supplier, mitochondria have their own DNA that could also be the potential target for platinum(IV) compounds. More importantly, mitochondrial DNA lacks its own repair mechanism and is more susceptible to the influence of the mitochondrial respiratory function.
URI: http://scholarbank.nus.edu.sg/handle/10635/138904
Appears in Collections:Ph.D Theses (Open)

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