HEALTH TECHNOLOGY ASSESSMENT OF NEW MODELS IN HEALTHCARE

Abstract

This PhD project conducts technology assessment, particularly exploring the cost-effectiveness of implementing new pharmacogenomic models of healthcare in Singapore. Besides its academic pursuits, it also aimed to provide scientific evidence and identify potentially valuable areas of future research to aid in translation of these technologies in real practice. Working with the NUS Saw Swee Hock School of Public Health, and public hospitals in Singapore, three important studies were identified as part of this project, which are at different stages of discovery and implementation – a technology with FDA recommendations for clinical implementation (HLA-B*5701 genotyping before abacavir), a technology with proven clinical utility but no recommendations by FDA (SLCO1B1 genotyping before simvastatin prescription) and a novel technology which is at the stage of clinical discovery and validation (miRNA serum test for gastric cancer diagnosis).