Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/138407
Title: PATZ1 MODULATES LIVER CANCER CELL PROLIFERATION BY POSITIVELY REGULATING CDKN1B
Authors: NG ZHEN LONG
Keywords: Liver cancer, PATZ1, CDKN1B, transcription factor, cell proliferation, gene expression profiling
Issue Date: 27-Oct-2017
Citation: NG ZHEN LONG (2017-10-27). PATZ1 MODULATES LIVER CANCER CELL PROLIFERATION BY POSITIVELY REGULATING CDKN1B. ScholarBank@NUS Repository.
Abstract: Liver cancer is the third most common cause of cancer death in the world. PATZ1 is a transcription factor associated with the progression of various cancers. However, the role of PATZ1 in liver cancer progression remains unclear. This study established that PATZ1 is highly expressed in hepatocellular carcinoma cells as compared to normal hepatocytes. Gene Ontology clustering of PATZ1 gene expression microarray and ChIP-Seq analyses revealed a role of PATZ1 in the cell proliferation of HepG2 cells. Consistently, knockdown of PATZ1 in HepG2 increased cell proliferation. This study further shows that PATZ1 binds to and regulates the expression of the cyclin-dependent kinase inhibitor CDKN1B in cooperation with p53. In summary, this study provides a novel mechanistic insight into the role of PATZ1 in liver cancer progression by its direct regulation of CDKN1B to modulate cell proliferation, thereby providing a promising therapeutic intervention for liver cancer.
URI: http://scholarbank.nus.edu.sg/handle/10635/138407
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
NgZL.pdf21.92 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

163
checked on Sep 18, 2020

Download(s)

6
checked on Sep 18, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.