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|Title:||AN ANISOTROPIC AND VASCULARIZING CELL-SEEDED PATCH FOR MYOCARDIAL REGENERATION||Authors:||MARIA CHRISTINE TANKEH ASUNCION||ORCID iD:||orcid.org/0000-0001-9163-0953||Keywords:||silk fibroin, tissue engineering, microparticles, cardiac tissue engineering, vegf delivery, unidirectional freezing||Issue Date:||16-Aug-2017||Citation:||MARIA CHRISTINE TANKEH ASUNCION (2017-08-16). AN ANISOTROPIC AND VASCULARIZING CELL-SEEDED PATCH FOR MYOCARDIAL REGENERATION. ScholarBank@NUS Repository.||Abstract:||As cardiovascular diseases remain to be a leading cause of death worldwide, different strategies are currently being explored as alternatives to heart transplantation. Due to the limited clinical success of cellular strategies and the higher risks involved in genetic therapies, the possibility of using cardiac tissue engineering to surgically restore heart function remains to be noteworthy of investigation. In this study, undirectional freezing was used to construct a silk-based cardiac patch to address the need for anisotropy to match native cardiac tissue. VEGF-loaded silk microparticles were incorporated to the patch as a vascularization strategy to attain a clinically-relevant thickness and finally, induced porcine bone marrow-derived mesenchymal stem cells were seeded into the growth factor-releasing scaffold. The resulting construct was an anisotropic and VEGF-releasing cell-seeded patch that could be used as a foundation for future in vivo studies in myocardial regeneration.||URI:||http://scholarbank.nus.edu.sg/handle/10635/138178|
|Appears in Collections:||Ph.D Theses (Open)|
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