Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/138103
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dc.titleNEURAL CIRCUITS MEDIATING INNATE BEHAVIORS IN LARVAL ZEBRAFISH
dc.contributor.authorKRISHNAN SEETHA LAKSHMI
dc.date.accessioned2017-12-27T18:00:27Z
dc.date.available2017-12-27T18:00:27Z
dc.date.issued2017-08-25
dc.identifier.citationKRISHNAN SEETHA LAKSHMI (2017-08-25). NEURAL CIRCUITS MEDIATING INNATE BEHAVIORS IN LARVAL ZEBRAFISH. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/138103
dc.description.abstractAnimals exhibit several innate defense behaviors essential for survival, that are developed and refined through evolution. For the behaviors to be effective, the nervous system must be able to detect cues that signify potential danger and generate an appropriate response. Here, in larval zebrafish, we investigate defense behaviors to visual and olfactory stimuli that represent potential threat. In the first case, we investigate the neural circuitry mediating innate dark avoidance. Using state of the art tools, we provide evidence for a circuit from the retina and thalamus to serotonergic raphe neurons that controls preference for light over darkness. In the second case, we investigate if larvae react to chemicals released from the skin of an injured conspecific, which drive defensive behaviors in adults. We observe that larval fish freeze with extreme fear upon exposure and set the stage to delineate the neural circuitry mediating this behavior.
dc.language.isoen
dc.subjectzebrafish, two-photon imaging, dark avoidance, alarm substance, habenula, thalamus
dc.typeThesis
dc.contributor.departmentDEAN'S OFFICE (NGS FOR INTGR SCI & ENGG)
dc.contributor.supervisorYEN SHIH-CHENG
dc.contributor.supervisorJESUTHASAN SURESH JEYARAJ
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.orcid0000-0003-1078-6353
Appears in Collections:Ph.D Theses (Open)

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