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Title: Pharmacological interventions in heat stress based on an animal model
Keywords: hsp70, hyperthermia, heat stress, herbimycin A, apoptosis, heat shock proteins
Issue Date: 22-Apr-2004
Citation: SHANKAR BABU SACHIDHANANDAM (2004-04-22). Pharmacological interventions in heat stress based on an animal model. ScholarBank@NUS Repository.
Abstract: A free moving rat model of heat stress was designed to test the effectiveness of herbimycin A in attenuating the effects of heat stress. Herbimycin A induced heat shock protein 70 (hsp70) in the liver, lung, heart and kidney tissues of rats, with peak levels 12 hours post IP treatment. Vehicle and saline treatment showed no change in corresponding hsp70 levels. Herbimycin A treated rats attained lower peak core temperatures following heat stress, 12 hours post treatment. They also had attenuated levels of apoptotic tissue 24 hours post heat stress, compared to vehicle and saline treated rats. The Cortemp sensor was just as effective as the rectal probe in recording body temperature during heat stress. Herbimycin A was able to attenuate temperature rise and apoptosis, due to heat stress exposure.
Appears in Collections:Master's Theses (Open)

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