Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/137902
Title: HUMAN OPTIC NERVE HEAD BIOMECHANICS : FINITE ELEMENT SIMULATIONS AND IN VIVO TISSUE STIFFNESS MEASUREMENTS
Authors: ZHANG LIANG
Keywords: glaucoma, biomechanics, virtual fields method, finite element, optic nerve head, stiffness estimation
Issue Date: 24-Aug-2017
Citation: ZHANG LIANG (2017-08-24). HUMAN OPTIC NERVE HEAD BIOMECHANICS : FINITE ELEMENT SIMULATIONS AND IN VIVO TISSUE STIFFNESS MEASUREMENTS. ScholarBank@NUS Repository.
Abstract: Glaucoma is the second leading cause for blindness. It is characterized by the axon damage at the optic nerve head (ONH) and is associated with elevated intraocular pressure (IOP). However, patients show different sensitivity to changes in IOP, which implies the potential role of the biomechanical properties of ONH tissues in the progression of glaucoma. This project explored the biomechanics of human ONH and its potential correlation with the progression of glaucoma. First, the mechanical role of collagen fibers was investigated using finite element modeling and sensitivity analyses, incorporating the fiber distribution information from small angle light scattering scanning of human ONH tissues. Second, a novel technique was developed to measure the material properties of the ONH tissues in vivo using the virtual fields method, from optical coherence tomography images at different IOP levels. Third, cross-sectional human studies were performed to extract the material properties of different human ONH groups.
URI: http://scholarbank.nus.edu.sg/handle/10635/137902
Appears in Collections:Ph.D Theses (Open)

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