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Title: GLP inhibits heterochromatin clustering and myogenic differentiation by repressing MeCP2
Authors: Choi, Min Hee
Palanichamy Kala, Monica
Ow, Jin Rong
Rao, Vinay Kumar
Suriyamurthy, Sudha
Keywords: chromatin
myogenic differentiation
Issue Date: 23-Aug-2017
Publisher: Oxford University Press
Citation: Choi, Min Hee, Palanichamy Kala, Monica, Ow, Jin Rong, Rao, Vinay Kumar, Suriyamurthy, Sudha, RESHMA TANEJA (2017-08-23). GLP inhibits heterochromatin clustering and myogenic differentiation by repressing MeCP2. Journal of molecular cell biology 10 (2) : 161-174. ScholarBank@NUS Repository.
Abstract: Myogenic differentiation is accompanied by alterations in the chromatin states, which permit or restrict the transcriptional machinery and thus impact distinctive gene expression profiles. The mechanisms by which higher-order chromatin remodeling is associated with gene activation and silencing during differentiation is not fully understood. In this study, we provide evidence that the euchromatic lysine methyltransferase GLP regulates heterochromatin organization and myogenic differentiation. Interestingly, GLP represses expression of the methyl-binding protein MeCP2 that induces heterochromatin clustering during differentiation. Consequently, MeCP2 and HP1γ localization at major satellites are altered upon modulation of GLP expression. In GLP knockdown cells, depletion of MeCP2 restored both chromatin organization and myogenic differentiation. These results identify a novel regulatory axis between a histone methylation writer and DNA methylation reader, which is important for heterochromatin organization during differentiation.
Source Title: Journal of molecular cell biology
ISSN: 16742788
DOI: 10.1093/jmcb/mjx038
Appears in Collections:Staff Publications

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