Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nlm.2016.07.017
DC FieldValue
dc.titleThe forebrain medial septal region and nociception
dc.contributor.authorANG SEOK TING
dc.contributor.authorMOHAMMED ZACKY ARIFFIN
dc.contributor.authorKhanna,Sanjay
dc.date.accessioned2017-12-11T01:25:11Z
dc.date.available2017-12-11T01:25:11Z
dc.date.issued2017-02-01
dc.identifier.citationANG SEOK TING, MOHAMMED ZACKY ARIFFIN, Khanna,Sanjay (2017-02-01). The forebrain medial septal region and nociception. Neurobiology of Learning and Memory 138 : 238-251. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nlm.2016.07.017
dc.identifier.issn10747427
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/137801
dc.description.abstractThe forebrain medial septum, which is an integral part of the septo-hippocampal network, is implicated in sensorimotor integration, fear and anxiety, and spatial learning and memory. A body of evidence also suggests that the septal region affects experimental pain. Indeed, some explorations in humans have raised the possibility that the region may modulate clinical pain as well. This review explores the evidence that implicates the medial septum in nociception and suggests that non-overlapping circuits in the region facilitate acute nociceptive behaviors and defensive behaviors that reflect affect and cognitive appraisal, especially in relation to persistent nociception. In line with a role in nociception, the region modulates nociceptive responses in the neuraxis, including the hippocampus and the anterior cingulate cortex. The aforementioned forebrain regions have also been implicated in persistent/long-lasting nociception. The review also weighs the effects of the medial septum on nociception vis-à-vis the known roles of the region and emphasizes the fact that the region is a part of network of forebrain structures which have been long associated with reward, cognition and affect-motivation and are now implicated in persistent/long-lasting nociception.
dc.language.isoen
dc.publisherElsevier
dc.subjectAffect
dc.subjectAversion
dc.subjectForebrain regulation
dc.subjectFormalin model
dc.subjectPersistent/long-lasting pain
dc.subjectSensorimotor
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1016/j.nlm.2016.07.017
dc.description.sourcetitleNeurobiology of Learning and Memory
dc.description.volume138
dc.description.page238-251
dc.identifier.isiut000395969400024
dc.published.statePublished
dc.grant.idDPRT/944/09/14
dc.grant.idR-185-000-271-720
dc.grant.fundingagencyNational University of Singapore
dc.grant.fundingagencyNational Medical Research Council (Singapore)
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