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Title: Engineering Noble Metal Nanoclusters for Enhanced Antimicrobial Effects and Systematic Investigation on their Mechanisms
Keywords: silver nanoclusters, gold nanoclusters, silver nanoparticles, antimicrobial agents, antimicrobial mechanisms, reactive oxygen species
Issue Date: 14-Aug-2017
Citation: ZHENG KAIYUAN (2017-08-14). Engineering Noble Metal Nanoclusters for Enhanced Antimicrobial Effects and Systematic Investigation on their Mechanisms. ScholarBank@NUS Repository.
Abstract: Antimicrobial resistance is one of the greatest health threats worldwide, so alternative powerful antimicrobial agents are urgently needed. The silver (Ag) nanomaterials are attractive broad-spectrum antimicrobial agents. We summarized the physicochemical properties of Ag nanomaterials, and found that size could determine antimicrobial efficiency. Therefore, we used ultrasmall metal nanoclusters (NCs) less than 2 nm as model to improve antimicrobial efficiency. Firstly, we synthesized ultrastable luminescent Ag NCs through aggregation-induced emission (AIE). Next, we improved antimicrobial efficiency through conjugation of Ag NCs with a commercial antibiotics daptomycin to achieve synergistic effects. The conjugation could effectively kill bacteria with complementary antimicrobial mechanisms. Moreover, commonly believed inert and noble gold (Au) was found to show unexpected antimicrobial effect in Au NCs form. The Au NCs could kill both Gram-positive and Gram-negative bacteria by generating reactive oxygen species (ROS), thus disturbing the normal metabolism of bacteria to kill them. In addition, we found the surface ligand of Au NCs could influence their antimicrobial efficiency, and the mechanism behind was explored.
Appears in Collections:Ph.D Theses (Open)

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