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|Title:||ROLE OF CYTOKINES AND GLIAL CELLS IN PAIN MODELS: NOCICEPTIVE (OSTEOARTHRITIS) AND NEUROPATHIC (PACLITAXEL-INDUCED) PAIN||Authors:||LIU WEILING||Keywords:||Chronic pain, Osteoarthritis, Interleukin-6, Paclitaxel, Cytokine, Glia||Issue Date:||21-Aug-2017||Citation:||LIU WEILING (2017-08-21). ROLE OF CYTOKINES AND GLIAL CELLS IN PAIN MODELS: NOCICEPTIVE (OSTEOARTHRITIS) AND NEUROPATHIC (PACLITAXEL-INDUCED) PAIN. ScholarBank@NUS Repository.||Abstract:||Chronic pain which persists over long periods of time is a disease that can impact greatly on one’s life. The underlying pathophysiology of pain is not well elucidated. There are changes in the adaptive neuroplasticity related to chronic pain pathway. Activated glial cells are capable of releasing signaling molecules like cytokines in its modulatory role of pain. In this study, we investigated nociceptive pain looking at effect of cerebrospinal fluid of patients with knee osteoarthritis comparing to those without pain on a human glioblastoma cell line, T98G. Interleukin-6 release by T98G cells was higher in those triggered by OA pain CSF. A paclitaxel-evoked peripheral neuropathy rat model was also explored. Behavioural tests showed significant mechanical sensitivity in paclitaxel-induced rats. There was no significant difference in lumbar spinal cord for the various targets: tumour necrosis factor-alpha, interleukin-10, microglia marker Iba-1. However, higher astrocyte marker GFAP protein expression was seen post-paclitaxel treatment.||URI:||http://scholarbank.nus.edu.sg/handle/10635/137482|
|Appears in Collections:||Master's Theses (Open)|
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