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|Title:||VITAMIN E ISOFORM ¿-TOCOTRIENOL ALLEVIATES ASTHMA AND COPD||Authors:||PEH HONG YONG||Keywords:||Inflammation, Oxidative Damage, Airway Hyperresponsiveness, Emphysema, Antioxidant, Corticosteroid||Issue Date:||16-Oct-2017||Citation:||PEH HONG YONG (2017-10-16). VITAMIN E ISOFORM ¿-TOCOTRIENOL ALLEVIATES ASTHMA AND COPD. ScholarBank@NUS Repository.||Abstract:||Inflammation and oxidative stress contribute to the pathogenesis of both asthma and chronic obstructive pulmonary disease (COPD). Although corticosteroid is the first-line treatment for asthma and COPD, a subset of patients is steroid-resistant, and chronic steroid use causes side effects. As vitamin E isoform γ-tocotrienol possesses both anti-oxidative and anti-inflammatory properties, we aimed to determine effects of γ-tocotrienol in a house dust mite (HDM) experimental asthma model and cigarette smoke experimental COPD model. We have shown for the first time the efficacy of vitamin E isoform γ-tocotrienol in protection against HDM-induced asthma and cigarette smoke-induced COPD by direct neutralization of free radicals, abating oxidative damage, and restoring antioxidants activities, coupled with anti-inflammatory actions in the injured airways. Mechanistically, γ-tocotrienol was found to block nuclear STAT3 and NF-κB level, and enhance nuclear Nrf2 levels in lung lysates to greater extents than prednisolone.||URI:||http://scholarbank.nus.edu.sg/handle/10635/137144|
|Appears in Collections:||Ph.D Theses (Open)|
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