Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bandc.2017.05.002
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dc.titleThe influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants
dc.contributor.authorQuan, J.
dc.contributor.authorOng, M.-L.
dc.contributor.authorBureau, J.-F.
dc.contributor.authorSim, L.W.
dc.contributor.authorSanmugam, S.
dc.contributor.authorAbdul Malik, A.B.
dc.contributor.authorWong, E.
dc.contributor.authorWong, J.
dc.contributor.authorChong, Yap Seng
dc.contributor.authorQiu, A.
dc.contributor.authorHolbrook, J.D.
dc.contributor.authorRifkin-Graboi, A.
dc.contributor.authorSaw, Seang Mei
dc.contributor.authorKwek, K.
dc.contributor.authorQiu, Anqi
dc.date.accessioned2017-10-06T00:39:32Z
dc.date.available2017-10-06T00:39:32Z
dc.date.issued2017-08
dc.identifier.citationQuan, J., Ong, M.-L., Bureau, J.-F., Sim, L.W., Sanmugam, S., Abdul Malik, A.B., Wong, E., Wong, J., Chong, Yap Seng, Qiu, A., Holbrook, J.D., Rifkin-Graboi, A., Saw, Seang Mei, Kwek, K., Qiu, Anqi (2017-08). The influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants. Brain and Cognition 116 : 17-28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bandc.2017.05.002
dc.identifier.issn02782626
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/136819
dc.description.abstractDespite claims concerning biological mechanisms sub-serving infant attention, little experimental work examines its underpinnings. This study examines how candidate polymorphisms from the cholinergic (CHRNA4 rs1044396) and dopaminergic (COMT rs4680) systems, respectively indicative of parietal and prefrontal/anterior cingulate involvement, are related to 6-month-olds’ (n = 217) performance during a visual expectation eye-tracking paradigm. As previous studies suggest that both cholinergic and dopaminergic genes may influence susceptibility to the influence of other genetic and environmental factors, we further examined whether these candidate genes interact with one another and/or with early caregiving experience in predicting infants’ visual attention. We detected an interaction between CHRNA4 genotype and observed maternal sensitivity upon infants’ orienting to random stimuli and a CHRNA4-COMT interaction effect upon infants’ orienting to patterned stimuli. Consistent with adult research, we observed a direct effect of COMT genotype on anticipatory looking to patterned stimuli. Findings suggest that CHRNA4 genotype may influence susceptibility to other attention-related factors in infancy. These interactions may account for the inability to establish a link between CHRNA4 and orienting in infant research to date, despite developmental theorizing suggesting otherwise. Moreover, findings suggest that by 6 months, dopamine, and relatedly, the prefrontal cortex/anterior cingulate, may be important to infant attention. © 2017 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bandc.2017.05.002
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectCHRNA4
dc.subjectCOMT
dc.subjectExecutive attention
dc.subjectGene-environment interaction
dc.subjectMaternal sensitivity
dc.subjectOrienting attention
dc.typeArticle
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1016/j.bandc.2017.05.002
dc.description.sourcetitleBrain and Cognition
dc.description.volume116
dc.description.page17-28
dc.identifier.isiut000405258900003
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.published.statePublished
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idSICS/YIG/2013/002
dc.grant.idNMRC/CBRG/0039/2013
dc.grant.fundingagencyNational Medical Research Council (NMRC)
dc.grant.fundingagencyAgency for Science, Technology and Research (A∗STAR)
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