Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/136740
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dc.titleNEUROPROTECTIVE EFFECT OF FLUOCINOLONE ACETONIDE ON MITOCHONDRIA IN PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY
dc.contributor.authorLEE JI CHAO TRISTAN
dc.date.accessioned2017-09-30T18:00:30Z
dc.date.available2017-09-30T18:00:30Z
dc.date.issued2017-06-02
dc.identifier.citationLEE JI CHAO TRISTAN (2017-06-02). NEUROPROTECTIVE EFFECT OF FLUOCINOLONE ACETONIDE ON MITOCHONDRIA IN PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/136740
dc.description.abstractOne side effect of paclitaxel treatment, an established chemotherapy drug, is neurotoxicity, which may lead to Paclitaxel-Induced Peripheral Neuropathy (PIPN). Paraesthesia, tingling and numbness from PIPN may result in dose reduction or premature termination of the life-saving chemotherapy. Nerves with long axons are more sensitive to paclitaxel toxicity and this can be attributed to the fact that long axons are more susceptible to the dysregulation of mitochondrial dynamics. A novel mitochondrial dual-labelling method was devised, utilising the unique advantage of a compartmentalised neuron culture system. Fluocinolone Acetonide (FA), a hydrocortisone derivative, induced significant anterograde trafficking of proximal mitochondria (PM) into distal axons as a neuroprotective mechanism against PIPN. This phenomenon mitigates the damage to the distal mitochondria (DM) population and protects the axons from neurodegeneration. FA treatment recovered the paclitaxel-induced neurotoxic changes in mitochondria dynamics suggesting that its neuroprotective mechanism involved the drug-induced engagement and rescue of the mitochondria network.
dc.language.isoen
dc.subjectCIPN, Trafficking, PNS, Neuroprotection, Live-cell imaging
dc.typeThesis
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.supervisorTHAKOR, NITISH VYOMESH
dc.description.degreeMaster's
dc.description.degreeconferredMASTER OF ENGINEERING
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Master's Theses (Open)

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