SLEEP DISORDERED BREATHING AND CARDIOVASCULAR DISEASE

Abstract

Sleep disordered breathing (SDB), with a rising global prevalence due to obesity epidemic, has been shown to be associated with cardiovascular diseases. However, this disease is under-recognized and improved detection is required for timely intervention. Using a FDA-approved portable diagnostic device and complex statistical modeling, the population estimate of SDB in Singapore was high at 30.5%, with Chinese and Malays more likely to be affected than Indians. Public awareness of SDB was poor. All three SDB screening questionnaires (STOP-BANG, Berlin Questionnaire and NoSAS score) have potential use as preliminary screening tools. Berlin Questionnaire was superior to the other two in predicting exercise fitness among patients attending cardiac rehabilitation. Among individuals attending health screening, SDB was detected in 38%. SDB was found to be independently associated with high serum levels of high-sensitivity C-reactive protein and triglyceride, and low exercise capacity. Incorporation of SDB screening into health screening programs seems feasible.