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|Title:||DESIGN OF A 3D PRINTED TENDON GRAFT SLEEVE FOR OSTEOINTEGRATION ENHANCEMENT||Authors:||PNG SI NING||Keywords:||anterior cruciate ligament, silk, 3D printing, sleeve, bioink, silk/SDS/Pluronic||Issue Date:||12-Apr-2017||Citation:||PNG SI NING (2017-04-12). DESIGN OF A 3D PRINTED TENDON GRAFT SLEEVE FOR OSTEOINTEGRATION ENHANCEMENT. ScholarBank@NUS Repository.||Abstract:||The gold standard for anterior cruciate ligament (ACL) reconstruction is the bone-tendon-bone autograft. However, osteointegration and the histological transition between tendon graft and host bone at the bone graft-host bone interface is still elusive. In order to augment healing after ACL reconstruction, a 3D printable tendon graft sleeve is designed and developed for osteointegration enhancement at the bone graft-host bone interface. The different sleeve designs were designed with AutoCAD, 3D printed and tested for its efficacy, pull-through strength, physical and mechanical properties. Simultaneously, a 3D printable silk-based bioink is being developed and tested as a replacement biocompatible material for current non-biocompatible 3D printing inks. It can be concluded that the printed graft sleeve design is a reproducible alternative for current tissue augmentation devices and that the silk/SDS/Pluronic blend may be a prospective biocompatible bio ink for the printing of such a graft sleeve device for application in ACL reconstruction.||URI:||http://scholarbank.nus.edu.sg/handle/10635/136239|
|Appears in Collections:||Master's Theses (Open)|
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