Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/136200
Title: GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
Authors: XU SHENYAO
Keywords: gold nanoparticles, glycosaminoglycans, breast cancer, hyaluronic acid, chondroitin sulfate, targeted therapy
Issue Date: 29-Mar-2017
Citation: XU SHENYAO (2017-03-29). GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY. ScholarBank@NUS Repository.
Abstract: Studies have reported that breast cancer has become one of the most common cancers in the world. CD44 is a biomarker that is overexpressed in most types of cancer cells, including breast cancer. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate A (CSA), are known as binding ligands of CD44 receptor and were used as non-toxic targeting ligands in targeted cancer therapy. Gold nanoparticles have been demonstrated to be highly useful for enhancing the delivery efficacy of a wide range of compounds. In this study, AuNP-oHA and AuNP-CS were synthesized using the ‘one-pot’ synthesis method. Both AuNP-oHA and AuNP-CS exhibited selective cytotoxicity to cancerous cells, showing that these two AuNPs can be potential chemotherapeutic agents that are specific to CD44-overexpressed breast cancer therapy. Furthermore, AuNP-oHA can also be used as a targeted drug carrier due to its selective cell uptake in CD44-overexpressed cells.
URI: http://scholarbank.nus.edu.sg/handle/10635/136200
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