Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/136184
DC Field | Value | |
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dc.title | A CONTINUOUS AND SCALABLE BOTTOM-UP PROCESS TO PRODUCE NANOPARTICLE FORMULATIONS FOR ENHANCED DRUG DELIVERY | |
dc.contributor.author | HU JUN | |
dc.date.accessioned | 2017-07-18T18:00:17Z | |
dc.date.available | 2017-07-18T18:00:17Z | |
dc.date.issued | 2017-01-18 | |
dc.identifier.citation | HU JUN (2017-01-18). A CONTINUOUS AND SCALABLE BOTTOM-UP PROCESS TO PRODUCE NANOPARTICLE FORMULATIONS FOR ENHANCED DRUG DELIVERY. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/136184 | |
dc.description.abstract | The aim of this study was to develop a process to produce pharmaceutical nanoformulations. A process was designed which can be used as a proof-of-concept at lab scale to mimic a process of continuous liquid antisolvent precipitation followed by immediate (on-line) spray drying. Feasibility studies were carried out on three model drugs (i.e. fenofibrate, budesonide and sodium cromoglicate). Through the proposed process, nanoformulations of two poorly water-soluble drugs (i.e. fenofibrate and budesonide) with lactose or mannitol as the matrix excipient and excipient-free nanoformulation of one water-soluble drug (i.e. sodium cromoglicate) were successfully produced. Characterization and comparison studies confirmed that the nanoformulations of these drugs exhibited much improved dissolution properties and/or enhanced aerosol performance as compared with conventional formulations containing microsized drug particles, indicating the potential of coupling liquid antisolvent precipitation with immediate (on-line) spray drying for the continuous and scalable production of pharmaceutical nanoformulations to achieve enhanced oral/pulmonary delivery. | |
dc.language.iso | en | |
dc.subject | Bottom-up, Nanoparticle, Nanoformulation, Liquid Antisolvent Precipitation, Immediate (on-line) Spray Drying, Enhanced Drug Delivery | |
dc.type | Thesis | |
dc.contributor.department | PHARMACY | |
dc.contributor.supervisor | PASTORIN, GIORGIA | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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HuJ.pdf | 3.64 MB | Adobe PDF | OPEN | None | View/Download |
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