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|Title:||ROLE OF TOPOGRAPHIC CUES ON CANCER CELL PROLIFERATION||Authors:||PARTHIV KANT CHAUDHURI||Keywords:||Cancer microenvironment, cancer cell proliferation, topographic cues, actomyosin contractility, mechanotransduction, mechanopathology||Issue Date:||17-Apr-2017||Citation:||PARTHIV KANT CHAUDHURI (2017-04-17). ROLE OF TOPOGRAPHIC CUES ON CANCER CELL PROLIFERATION. ScholarBank@NUS Repository.||Abstract:||Metastasis from a primary epithelial tumor is one of the main causes of cancer related deaths. Although the role of stiffness on proliferative response of cancer cells has been well studied, little is known about the effect of topographic cues in guiding cancer cell proliferation. Here, we examined the effect of topographic cues on cancer cell proliferation by fabricating micrometer scale topographic features. We observed that the proliferation response of non-cancer breast epithelial cells but not of malignant breast cancer cells decreases on the microgratings. Bone, which is composed of a porous matrix, is one of the principal secondary locations for cancer. We examined how the depth of the pores could transduce a mechanical signal and reduce the proliferation of cancer cells. Taken together, we observe the existence of Mechanically Induced Dormancy (MID) where topographical cues could inhibit the proliferation of breast cancer cells through differential regulation of actomyosin contractility.||URI:||http://scholarbank.nus.edu.sg/handle/10635/136182|
|Appears in Collections:||Ph.D Theses (Open)|
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