Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/136059
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dc.titleBEDAQUILINE TARGETS THE EPSILON SUBUNIT OF MYCOBACTERIAL F-ATP SYNTHASE
dc.contributor.authorSUBHASHRI KUNDU
dc.date.accessioned2017-06-30T18:00:44Z
dc.date.available2017-06-30T18:00:44Z
dc.date.issued2017-02-06
dc.identifier.citationSUBHASHRI KUNDU (2017-02-06). BEDAQUILINE TARGETS THE EPSILON SUBUNIT OF MYCOBACTERIAL F-ATP SYNTHASE. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/136059
dc.description.abstractThe tuberculosis drug Bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using purified ε subunit of the synthase and spectroscopy we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here we show that replacement of ε’s tryptophan with alanine resulted in Bedaquiline hyper susceptibility of the bacteria. Overexpression of wild type ε subunit caused resistance. These results suggest that the drug also targets the ε subunit.
dc.language.isoen
dc.subjectTMC207, Bedaquiline, target, epsilon, tuberculosis, subunit
dc.typeThesis
dc.contributor.departmentMICROBIOLOGY & IMMUNOLOGY
dc.contributor.supervisorTHOMAS DICK
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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