Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/135899
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dc.titleCHARACTERISATION OF NOVEL BACTERIAL FILAMENT SYSTEMS AND THEIR POTENTIAL AS ANTIBIOTIC TARGETS
dc.contributor.authorLEE LIN JIE
dc.date.accessioned2017-06-05T18:00:11Z
dc.date.available2017-06-05T18:00:11Z
dc.date.issued2017-01-17
dc.identifier.citationLEE LIN JIE (2017-01-17). CHARACTERISATION OF NOVEL BACTERIAL FILAMENT SYSTEMS AND THEIR POTENTIAL AS ANTIBIOTIC TARGETS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/135899
dc.description.abstractBacterial actin-like filament systems (such as ParM and MreB) are needed to carry out essential functions such as cell shape maintenance and plasmid segregation. The aim of the studying bacterial filaments is to understand their biological roles and to assess their potential as novel antibacterial drug targets. First, novel proteins Cb40 ParM and Cb20 ParM were found to assemble into distinct organisations with different sets of structural properties, suggesting that they may have dissimilar mechanisms for DNA segregation. Next, novel MreB-like protein TmMbl was found to be a potential modulator of TmMreB activity in the bacteria T. Maritima and it is likely to assist TmMreB in its cellular functions. Lastly, MreB inhibitors A22 and Mp265 were characterised, they induce MreB depolymerisation by causing conformational changes into its monomeric state. In conclusion, bacterial actin-like proteins (Alp) are great potential targets for a new class of antibiotic, but more work is needed to obtain better Alp perturbing compounds.
dc.language.isoen
dc.subjectBACTERIA, filament, mreb, parm, microscope, crystallography
dc.typeThesis
dc.contributor.departmentDEAN'S OFFICE (NGS FOR INTGR SCI & ENGG)
dc.contributor.supervisorROBERT CHARLES ROBINSON
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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