Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/135882
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dc.titleTARGETING THE PIK3 PATHWAY IN NON-SMALL CELL LUNG CANCER
dc.contributor.authorDANIEL TAN SHAO WENG
dc.date.accessioned2017-06-02T18:00:15Z
dc.date.available2017-06-02T18:00:15Z
dc.date.issued2016-06-01
dc.identifier.citationDANIEL TAN SHAO WENG (2016-06-01). TARGETING THE PIK3 PATHWAY IN NON-SMALL CELL LUNG CANCER. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/135882
dc.description.abstractThe phosphotidyl inositol (3) kinase (PI3K) pathway is a critical survival pathway that is subverted in many cancers, particularly those that are receptor tyrosine kinase driven. This thesis describes a multi-pronged approach to examine the relevance of this pathway in epidermal growth factor receptor mutation positive lung adenocarcinoma, the commonest subtype in Singapore. I used a combination of integrative genomics and other molecular assays to describe the prevalence of PI3K pathway alterations in our local population (Tan, IJC 2014). I further evaluated the role of PI3K inhibition in the clinic, gaining significant insights to the challenges in developing this class of compounds (Tan, ASCO Proceedings 2014), and generated a range of preclinical models to inform on the potential therapeutic niches. Finally, with expanding knowledge on intra-tumoral heterogeneity, I present the case for high precision genomic interrogation, in order to delineate mutational context to predict therapeutic vulnerabilities (Tan, WCLC 2015).
dc.language.isoen
dc.subjectPI3K pathway, EGFR mutant NSCLC, TKI resistance
dc.typeThesis
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.supervisorDANIEL G. TENEN
dc.contributor.supervisorTAN BOON OOI, PATRICK
dc.description.degreePh.D
dc.description.degreeconferredPHD IN CANCER BIOLOGY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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