Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/135882
Title: | TARGETING THE PIK3 PATHWAY IN NON-SMALL CELL LUNG CANCER | Authors: | DANIEL TAN SHAO WENG | Keywords: | PI3K pathway, EGFR mutant NSCLC, TKI resistance | Issue Date: | 1-Jun-2016 | Citation: | DANIEL TAN SHAO WENG (2016-06-01). TARGETING THE PIK3 PATHWAY IN NON-SMALL CELL LUNG CANCER. ScholarBank@NUS Repository. | Abstract: | The phosphotidyl inositol (3) kinase (PI3K) pathway is a critical survival pathway that is subverted in many cancers, particularly those that are receptor tyrosine kinase driven. This thesis describes a multi-pronged approach to examine the relevance of this pathway in epidermal growth factor receptor mutation positive lung adenocarcinoma, the commonest subtype in Singapore. I used a combination of integrative genomics and other molecular assays to describe the prevalence of PI3K pathway alterations in our local population (Tan, IJC 2014). I further evaluated the role of PI3K inhibition in the clinic, gaining significant insights to the challenges in developing this class of compounds (Tan, ASCO Proceedings 2014), and generated a range of preclinical models to inform on the potential therapeutic niches. Finally, with expanding knowledge on intra-tumoral heterogeneity, I present the case for high precision genomic interrogation, in order to delineate mutational context to predict therapeutic vulnerabilities (Tan, WCLC 2015). | URI: | http://scholarbank.nus.edu.sg/handle/10635/135882 |
Appears in Collections: | Ph.D Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
TanDSW_PhDThesis.pdf | 18.31 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.