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|Title:||DIETARY POLYPHENOLS AND RISK OF TYPE 2 DIABETES MELLITUS IN ASIANS||Authors:||DERRICK JOHNSTON S/O ALPERET||Keywords:||Polyphenol, Phenolic Acid, Flavonoid, Type 2 Diabetes Mellitus, Diet, Nutrition.||Issue Date:||17-Jan-2017||Citation:||DERRICK JOHNSTON S/O ALPERET (2017-01-17). DIETARY POLYPHENOLS AND RISK OF TYPE 2 DIABETES MELLITUS IN ASIANS. ScholarBank@NUS Repository.||Abstract:||Escalation of Type 2 Diabetes Mellitus (T2DM) burden in Asia has been partly attributed to declining diet quality. While the roles of macro- and micronutrients in T2DM prevention have been sufficiently investigated, other components of diet (e.g. polyphenols) have yet to be conclusively evaluated, especially in Asians. Therefore, we evaluated two classes of polyphenols commonly consumed in the Asian diet: phenolic acids and flavonoids. In a 24-week randomized placebo-controlled trial, consumption of phenolic acid-rich coffee did not influence whole-body insulin sensitivity or biological mediators of insulin resistance in Asians. In prospective cohort studies among Asians, flavonoid-rich temperate fruits (such as apples and grapes) were associated with lower T2DM risk but individual flavonoid subclasses were not associated with lower T2DM risk. Our findings suggest that polyphenols are likely to modulate T2DM risk in Asians through intra- or interclass polyphenolic synergistic effects or through pathways different from those postulated in western populations.||URI:||http://scholarbank.nus.edu.sg/handle/10635/135726|
|Appears in Collections:||Ph.D Theses (Open)|
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