Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/135520
Title: ASSOCIATION OF TELOMERE LENGTH WITH AMYLOID PATHOLOGY IN CEREBRUM AND ITS ROLE IN DEMENTIA
Authors: GRISHMA RANE
Keywords: Telomere, Dementia, Amyloid pathology, Homocysteine, Mild cognitive impairment, meditation
Issue Date: 18-Aug-2016
Citation: GRISHMA RANE (2016-08-18). ASSOCIATION OF TELOMERE LENGTH WITH AMYLOID PATHOLOGY IN CEREBRUM AND ITS ROLE IN DEMENTIA. ScholarBank@NUS Repository.
Abstract: Telomere length (TL) is considered as a determinant of biological age, implicating a role in ageing diseases. In preliminary study TL was found to be associated with homocysteine, a strong and independent risk factor for stroke and dementia. Hence, we next focused on dementia and indeed observed a negative association of TL with plaque pathology score. The possibility of TL measurement early in disease development was investigated in subjects with mild cognitive impairment (MCI), an earlier stage of dementia. TL was not found to be significantly different from cases, however, mindfulness meditation practice was found to increase TL in MCI cases. Current work is to validate this finding in a larger cohort with subjects at different dementia stages. Together, these studies propose the possibility TL as a complementary predictive biomarker for AD. The rate of TL shortening would be important in predicting disease development, progression and efficacy of intervention trails.
URI: http://scholarbank.nus.edu.sg/handle/10635/135520
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