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|Title:||ENGINEERING CORE-SHELL STRUCTURED MICROSPHERES VIA COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION FOR PHARMACEUTICAL APPLICATIONS||Authors:||YAN WEI-CHENG||Keywords:||Coaxial electrohydrodynamic atomization, Core-shell microspheres, Microbubbles, CFD, Stroke, Ultrasound responsive||Issue Date:||10-Jan-2017||Citation:||YAN WEI-CHENG (2017-01-10). ENGINEERING CORE-SHELL STRUCTURED MICROSPHERES VIA COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION FOR PHARMACEUTICAL APPLICATIONS. ScholarBank@NUS Repository.||Abstract:||Core-shell microspheres exhibit remarkable advantages in drug delivery such as reduction in the initial burst release and enhancement in drug loading as compared to mono-layer polymer microspheres. Besides, the core-shell structure allows the achievement of synergistic therapeutic effects. These microspheres can be produced by coaxial electrohydrodynamic atomization (CEHDA) process. As one of the emerging fabrication techniques for core-shell microspheres, this process is receiving increasing attention in recent years. In the present work, the investigations covered not only the processing part but also the applications of CEHDA process for engineering core-shell microspheres. Both experimental and computational study were performed. The study was first focused on the development and optimization of this CEHDA process in terms of single nozzle system prior to large-scale production and multi-nozzle system towards large-scale production. In addition, the new applications of CEHDA in production of drug-loaded microbubbles (gas filled microspheres) were explored.||URI:||http://scholarbank.nus.edu.sg/handle/10635/135503|
|Appears in Collections:||Ph.D Theses (Open)|
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