Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/135465
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dc.titleMELT SPHERONIZATION - DIRECT ROTARY SHAPING PROCESS FOR HOT MELT EXTRUDATES
dc.contributor.authorTHIN YU TUN
dc.date.accessioned2017-04-30T18:00:55Z
dc.date.available2017-04-30T18:00:55Z
dc.date.issued2016-09-16
dc.identifier.citationTHIN YU TUN (2016-09-16). MELT SPHERONIZATION - DIRECT ROTARY SHAPING PROCESS FOR HOT MELT EXTRUDATES. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/135465
dc.description.abstractPellets are the primary units of multiparticulate pharmaceutical dosage forms, both as immediate or sustained release pellets. Due to their uniform shape and size, pellets offer biopharmaceutical advantages in terms of more even and predictable distribution and transportation in the gastrointestinal tract, which is fairly independent of the nutritional intake. Hot melt extrusion (HME) has emerged as an alternative “platform technology” for solid dosage form development in recent years. HME requires fewer processing steps or major downstream processing equipment and this clearly offers major advantages to new drug product development. HME with spheronization (collectively to be referred as melt spheronization) method can be used for developing solid dispersion pellets of poorly water-soluble drugs for solubility enhancement. Therefore, the objective of the study is to understand influence of formulation variables on the viscoelastic properties and impact of spheronization conditions on the physicomechanical properties of melt pellets. The study also aims to provide insights on the viability of spheroid development using the hot melt extrusion coupled with direct rotary shaping technique.
dc.language.isoen
dc.subjectMelt spheronization, Direct shaping, Hot melt extrusion, Melt Rheology, Melt Pellets, Multiparticulates
dc.typeThesis
dc.contributor.departmentPHARMACY
dc.contributor.supervisorHENG WAN SIA, PAUL
dc.contributor.supervisorRAJEEV GOKHALE
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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