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|Title:||ESTABLISHING AN EPITHELIAL MESENCHYMAL TRANSITION (EMT) SPECTRUM WITH EMT TRANSCRIPTIONAL DRIVERS||Authors:||TAN MING||Keywords:||EMT, EOC, transcription factors, FZD7, anoikis resistance, EMT spectrum||Issue Date:||18-Aug-2016||Citation:||TAN MING (2016-08-18). ESTABLISHING AN EPITHELIAL MESENCHYMAL TRANSITION (EMT) SPECTRUM WITH EMT TRANSCRIPTIONAL DRIVERS. ScholarBank@NUS Repository.||Abstract:||Epithelial-mesenchymal transition (EMT) refers to a sequential phenotypic transformation process from epithelial to mesenchymal states. In epithelial ovarian cancer (EOC), there is a dynamic EMT transcriptional regulatory network defined by EMT transcriptional drivers, SNAI1, TWIST1, ZEB1, and ZEB2, to further define the EMT phenotypic spectrum. The evolvement in the transcriptional regulatory loops correlated with the differences of in vitro EMT functions. The ability of TWIST1 to induce anoikis resistance, with upregulation of anti-apoptotic protein BCL2 as a marker, made it a downstream effector of WNT pathway receptor FZD7 (Frizzled-7). FZD7 regulated TWIST1 expression through epigenetic modification of H3K4me3 and the FZD7-TWIST1 axis correlated with lower level of global histone acetylation and can be targeted by porcupine inhibitor.||URI:||http://scholarbank.nus.edu.sg/handle/10635/135452|
|Appears in Collections:||Ph.D Theses (Open)|
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