Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13223-016-0161-x
DC FieldValue
dc.titlePredictors of allergen sensitization in Singapore children from birth to 3 years
dc.contributor.authorLoo, E. X.
dc.contributor.authorJ. Z. Sim
dc.contributor.authorA. Goh
dc.contributor.authorO. H. Teoh
dc.contributor.authorY. H. Chan
dc.contributor.authorS. M. Saw
dc.contributor.authorK. Kwek
dc.contributor.authorP. D. Gluckman
dc.contributor.authorK. M. Godfrey
dc.contributor.authorH. Van Bever
dc.contributor.authorY. S. Chong
dc.contributor.authorB. W. Lee
dc.contributor.authorM. S. Kramer
dc.contributor.authorL. P. Shek
dc.date.accessioned2017-04-19T08:59:42Z
dc.date.available2017-04-19T08:59:42Z
dc.date.issued2016-10-24
dc.identifier.citationLoo, E. X., J. Z. Sim, A. Goh, O. H. Teoh, Y. H. Chan, S. M. Saw, K. Kwek, P. D. Gluckman, K. M. Godfrey, H. Van Bever, Y. S. Chong, B. W. Lee, M. S. Kramer, L. P. Shek (2016-10-24). Predictors of allergen sensitization in Singapore children from birth to 3 years. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 12 (1) : Article number 56. ScholarBank@NUS Repository. https://doi.org/10.1186/s13223-016-0161-x
dc.identifier.issn17101484
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/135334
dc.description.abstractBackground: Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age. Objective: To determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards healthy outcomes (GUSTO) prospective birth cohort study. Methods: Interviewers collected information on demographics, family history of allergy, social and lifestyle factors, and the child's health. We analyzed data from 849 children who completed skin prick testing (SPT) to inhalant allergens (house dust mites: Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia tropicalis) and food allergens (egg, peanut and cow's milk) to assess risk factors for allergen sensitization at 18 months. To ensure that clinical phenotypes preceded allergen sensitization, we also analyzed data from 649 children who had a negative skin prick test at 18 months and completed skin prick testing at 36 months. Results: We observed a significant association between eczema reported before 18 months and a positive SPT at 18 months [aOR 4.5 (1.9-10.7)]. Ninety-five (14.6 %) children with negative SPTs at 18 months developed positive tests at 36 months. Onset of eczema before 18 months was associated with an increased risk of new allergen sensitization at 36 months among children non-sensitized at 18 months [aOR 3.4 (1.2-9.3)]. An association was seen between wheeze reported before 18 months and new allergen sensitization at 36 months [aOR 3.2 (1.1-9.1)]. We found no significant association, however, between rhinitis reported before 18 months and new allergen sensitization at 36 months. Conclusions: Early onset of eczema and wheeze are risk factors for later allergen sensitization, suggesting a possible increased susceptibility to allergen exposure through an impaired skin barrier or defective airway epithelium. Trial registration NCT01174875 Registered 1 July 2010, retrospectively registered � 2016 The Author(s).
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1186/s13223-016-0161-x
dc.publisherBioMed Central Ltd.
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1186/s13223-016-0161-x
dc.description.sourcetitleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
dc.description.volume12
dc.description.issue1
dc.description.pageArticle number 56
dc.identifier.isiut000386093600003
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.published.statePublished
dc.grant.idNMRC/CSA/022/2010
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idNRF370062-HUJ-NUS
dc.grant.fundingagencyNMRC, National Medical Research Council
dc.grant.fundingagencyNRF, National Research Foundation Singapore
dc.grant.fundingagencyAgency for Science, Technology and Research (Singapore)
dc.grant.fundingagencyNIHR Southampton Biomedical Research Centre
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2016-Predictors_allergen_sensitization_Singapore_children-pub.pdf934.38 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

14
checked on Nov 30, 2021

WEB OF SCIENCETM
Citations

10
checked on Nov 23, 2021

Page view(s)

416
checked on Nov 18, 2021

Download(s)

502
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.