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|Title:||APPROACHES TO PHARMACOGENOMICS TRANSLATION IN PUBLIC HEALTH||Authors:||TAN-KOI WEI CHUEN||Keywords:||Pharmacogenomics, Translation, Implementation, Regulatory, Cost-effectiveness, Communications||Issue Date:||16-Nov-2016||Citation:||TAN-KOI WEI CHUEN (2016-11-16). APPROACHES TO PHARMACOGENOMICS TRANSLATION IN PUBLIC HEALTH. ScholarBank@NUS Repository.||Abstract:||Stratified medicine is one of the two key areas highlighted by OECD that will significantly impact public health in the era of genomics. However, despite the past fifteen years of astounding advancements in the field of genomics, the translation between basic research linking mutation and drug response to clinical practice has been slow, even in the field of pharmacogenomics, where the burden of adverse drug reactions in the United States alone stands at more than two million hospitalised patients and is the fourth leading cause of death. Therefore, the aim of this thesis is to examine the science behind implementing stratified medicine in the paradigm of clinical translation, focusing on key issues of drug regulations, health technology assessment and communications. This thesis in totality comprises cross-disciplinary research and provides practical considerations in real world setting towards workable national strategies in the adoption of pharmacogenetics as part of routine clinical care.||URI:||http://scholarbank.nus.edu.sg/handle/10635/135258|
|Appears in Collections:||Ph.D Theses (Open)|
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