Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/13520
DC Field | Value | |
---|---|---|
dc.title | Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones | |
dc.contributor.author | LIU MEI | |
dc.date.accessioned | 2010-04-08T10:33:50Z | |
dc.date.available | 2010-04-08T10:33:50Z | |
dc.date.issued | 2003-10-24 | |
dc.identifier.citation | LIU MEI (2003-10-24). Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/13520 | |
dc.description.abstract | The focus of this thesis is the investigation of the antimalarial activities of oxygenated chalcones. A series of 102 chalcones, distinguished by their B ring substitution patterns as alkoxylated or hydroxylated members, were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum K1. Cytotoxicity tests indicated that the chalcones specifically target Plasmodium. Active members were tested in vivo against P. berghei infected mice. Significant correlations between in vitro antimalarial activity and physicochemical properties of the active chalcones led to a proposed quantitative structure-activity relationship model with good predictive ability. Investigations were also made to establish the structural requirements of antimalarial and antileishmanial chalcones. The effects of chalcones on the degradation of hemoglobin were investigated. Several chalcones demonstrated binding to hematin and inhibition of plasmodial cysteine protease. Unfortunately, there was no consistent correlation to antimalarial activity and the mode of action of these compounds in malaria remains an open question. | |
dc.language.iso | en | |
dc.subject | antimalarial activty, alkoxylated chalcones, hydroxylated chalcones, structure-activity relationship, mode of action, antileishmanial activity. | |
dc.type | Thesis | |
dc.contributor.department | PHARMACY | |
dc.contributor.supervisor | GO MEI LIN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
LiuMeiCover-Chap4.pdf | 881.35 kB | Adobe PDF | OPEN | None | View/Download | |
LiuMeiChap5.pdf | 789.66 kB | Adobe PDF | OPEN | None | View/Download | |
LiuMeiChap6-end.pdf | 665.89 kB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.