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|Title:||CHARACTERIZATION OF ARABIDOPSIS NUCLEOPORIN 160 IN THE CONTROL OF FLOWERING TIME||Authors:||LI CHUNYING||Keywords:||Flowering time, Arabidopsis, NPC, Nup160, HOS1||Issue Date:||10-Jan-2017||Citation:||LI CHUNYING (2017-01-10). CHARACTERIZATION OF ARABIDOPSIS NUCLEOPORIN 160 IN THE CONTROL OF FLOWERING TIME. ScholarBank@NUS Repository.||Abstract:||Nuclear pore complexes (NPCs) are large protein complexes embedded in the nuclear envelope as a selective gate for nucleocytoplasmic trafficking of macromolecules. Additionally, NPCs also function as scaffolds that spatially confine certain biological processes. Here we show that one conserved scaffold NPC component, Nucleoporin 160 (Nup160), plays an important role in controlling flowering time via HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 (HOS1), which activates FLOWERING LOCUS C (FLC) expression and destabilizes CONSTANS (CO) proteins in Arabidopsis. Nup160 is required for maintaining an appropriate amount of HOS1 protein at the nuclear envelope, which is essential for HOS1 to exert proper functions, although Nup160 does not affect general NPC assembly. Taken together, our findings suggest that Nup160 regulates dynamic deposition of HOS1 at the nuclear envelope to mediate flowering time in Arabidopsis.||URI:||http://scholarbank.nus.edu.sg/handle/10635/135149|
|Appears in Collections:||Ph.D Theses (Open)|
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