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|Title:||EPIGENETIC TIMING CONTROL OF WUSCHEL COORDINATES SHOOT APICAL MERISTEM AND FLORAL DEVELOPMENT IN ARABIDOPSIS||Authors:||LOOI LIANG SHENG||Keywords:||ARABIDOPSIS, MERISTEM, WUSCHEL, CLAVATA, KNUCKLES, FLOWERING||Issue Date:||15-Dec-2016||Citation:||LOOI LIANG SHENG (2016-12-15). EPIGENETIC TIMING CONTROL OF WUSCHEL COORDINATES SHOOT APICAL MERISTEM AND FLORAL DEVELOPMENT IN ARABIDOPSIS. ScholarBank@NUS Repository.||Abstract:||In the Arabidopsis shoot, indeterminate Shoot Apical Meristems (SAMs) continuously produce the above-ground organs. During reproductive development, SAM generates the Floral Meristems (FMs) at its periphery. In the SAM, the WUSCHEL-CLAVATA (WUS-CLV) pathway regulates the shoot meristems, whereas the WUSCHEL-AGAMOUS (WUS-AG) pathway regulates FM termination. The homeodomain transcription factor WUS is a primary modular regulated in both pathways. Firstly, I highlight that AG induces KNUCKLES (KNU) in a cell-division manner via invoking Polycomb Responsive Complex 2 (PRC2) removal, as preceding stage for WUS silencing in FM. Secondly, I show that the CLV pathway induces phosphorylation change of TOPLESS (TPL), a transcriptional corepressor, to regulate WUS expression in both SAM and FM. I propose that TPL phosphorylation regulates its protein-protein interaction, thereby affecting the WUS self-regulatory mechanism. In summary, I outline a model in understanding SAM homeostasis and floral organogenesis, which have significant values in plant biological development and applications.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134994|
|Appears in Collections:||Ph.D Theses (Open)|
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