Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134923
DC FieldValue
dc.titlePATTERNED EXTRACELLULAR TOPOGRAPHICAL CUES FOR CORNEAL ENDOTHELIAL MONOLAYER REGENERATION
dc.contributor.authorRIZWAN MUHAMMAD
dc.date.accessioned2017-02-28T18:00:50Z
dc.date.available2017-02-28T18:00:50Z
dc.date.issued2016-08-08
dc.identifier.citationRIZWAN MUHAMMAD (2016-08-08). PATTERNED EXTRACELLULAR TOPOGRAPHICAL CUES FOR CORNEAL ENDOTHELIAL MONOLAYER REGENERATION. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/134923
dc.description.abstractCornea is one of the most transplanted tissues in the world. The most common indication for corneal transplantation is corneal endothelium dysfunction. Donor cornea is the only available solution for endothelium dysfunction patients. The donor cornea shortage presents huge challenges for the ever-growing patients in need of donor corneal transplants. Consequently, alternative treatments such as cell regenerative therapies and tissue-engineered monolayer by using in-vitro cultivated primary human corneal endothelial cells are being investigated. This thesis examined the importance of patterned extracellular topographical cues for the in-vitro cultivation of HCECs and investigated their use in corneal cell regenerative therapies and tissue engineered monolayer. Furthermore, a natural biopolymer hydrogel was designed and a generic method was developed to pattern the hydrogel films with micro- and nano-topographical cues. These patterned hydrogel films were studied as an implantable cell-carrier device for the formation and transplantation of functionally improved HCEC monolayer.
dc.language.isoen
dc.subjectBiomaterials, Tissue engineering, cornea, hydrogels, nano-fabrication, endothelial monolayer
dc.typeThesis
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.supervisorTOH YI-CHIN
dc.contributor.supervisorYIM KING FAI, EVELYN
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
RizwanM_A0104469A_17Jan2017.pdf6.24 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

146
checked on Jul 12, 2019

Download(s)

80
checked on Jul 12, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.