Please use this identifier to cite or link to this item:
Title: Novel biochemical and functional properties of the HPV-16 oncoprotein E6
Keywords: HPV, E6, CBP, Zinc, Chelator, Metallochaperone
Issue Date: 29-Oct-2003
Citation: ROLAND DEGENKOLBE (2003-10-29). Novel biochemical and functional properties of the HPV-16 oncoprotein E6. ScholarBank@NUS Repository.
Abstract: Cervical carcinomas cause ~250,000 deaths per year worldwide, virtually all contain human papillomavirus DNA with 60% of them identified as HPV16. One of the two main oncoproteins is a??early protein 6a?? (E6) which targets p53 for degradation. E6 is expressed throughout cancer progression, necessary for the survival of the cancer cell and thus makes for an excellent drug target. Here, I present a novel way for the preparation and stabilization of high concentrations of monomeric E6, a prerequisite for structural studies, and evidence for the inherently flexible disposition of the E6 protein reflected in its large number of interaction partners, of which CBP/p300 is introduced here.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
DegenkolbeR.pdf7.09 MBAdobe PDF



Page view(s)

checked on Apr 8, 2019


checked on Apr 8, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.