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|Title:||GENES, ENVIRONMENT AND THEIR INTERACTION EFFECTS ON CORONARY ARTERY DISEASE AND ITS RISK FACTORS||Authors:||YI HAN||Keywords:||Coronary artery disease, genome-wide association study, Singaporean Chinese Population, gene-environment interaction study, meta-analysis, PON1||Issue Date:||15-Aug-2016||Citation:||YI HAN (2016-08-15). GENES, ENVIRONMENT AND THEIR INTERACTION EFFECTS ON CORONARY ARTERY DISEASE AND ITS RISK FACTORS. ScholarBank@NUS Repository.||Abstract:||Genetic predisposition is a fundamental determinant for CAD. The aims of my study were to unveil genetic basis of CAD by the GWAS approach, and to address the missing heritability of CAD by including gene-environment interaction analysis. In Study I, a mate-analysis of GWAS was conducted from two Singaporean Chinese studies. We replicated the association of the CDKN2A/2B locus and showed a strong association between a combined GRS of 34 index SNPs and CAD risk, suggesting that some common variants that were identified predominantly from Caucasian populations are to some extent relevant for CAD risks in the Singaporean Chinese population. In Study II, two SNPs at the PON1 gene, rs662 and rs3735590, were found to interact with cigarette smoking to modulate CAD risk from genetic epidemiological study. Study III showed a novel interaction between CLOCK variant rs1801260 and short sleep duration on BMI in the Singaporean Chinese population.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134813|
|Appears in Collections:||Ph.D Theses (Open)|
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