Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134715
Title: HARNESSING MOLECULAR MECHANISMS OF DRUG RESISTANCE TO REVERT RESISTANCE TO TOP2 INHIBITORS (DOXORUBICIN)
Authors: CORONEL CARRION LUIS EDUARDO
Keywords: drug, resistance, doxorubicin, top2, revert, inhibitors
Issue Date: 18-Aug-2016
Citation: CORONEL CARRION LUIS EDUARDO (2016-08-18). HARNESSING MOLECULAR MECHANISMS OF DRUG RESISTANCE TO REVERT RESISTANCE TO TOP2 INHIBITORS (DOXORUBICIN). ScholarBank@NUS Repository.
Abstract: Drug resistance in chemotherapy remains as one of the major hurdles in current cancer therapy. Therefore, this thesis aims to investigate the molecular mechanisms underlying drug resistant phenomena, identify new target pathways involved in resistance phenomena, and develop new strategies in tackling drug resistance. Cells resistant to Topoisomerase 2 inhibitors (e.g. Doxorubicin) were generated and two major pathways were found to be upregulated in a microarray analysis, namely, the MMR pathway and the fatty acid synthesis pathway. This reflects changes in the DNA repair capacity and basal metabolism in these cells. Interestingly, a novel role for non canonical mismatch repair (nc-MMR) was implicated in the drug resistant phenomenon observed in Dox-R cells. Unexpectedly, platinum based compounds (Cisplatin, Carboplatin, and Oxaliplatin) were found to sensitize Dox-R cells, further demonstrating that drug resistant mechanisms may be unique to different classes of chemotherapeutic drugs.
URI: http://scholarbank.nus.edu.sg/handle/10635/134715
Appears in Collections:Ph.D Theses (Open)

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