Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134711
DC FieldValue
dc.titlePERTURBATION IN IMMUNE-METABOLIC FUNCTION ASSOCIATED WITH OBESITY INDUCED INSULIN RESISTANCE IN HUMANS
dc.contributor.authorEHSAN PARVARESH RIZI
dc.date.accessioned2017-02-03T18:00:13Z
dc.date.available2017-02-03T18:00:13Z
dc.date.issued2016-08-08
dc.identifier.citationEHSAN PARVARESH RIZI (2016-08-08). PERTURBATION IN IMMUNE-METABOLIC FUNCTION ASSOCIATED WITH OBESITY INDUCED INSULIN RESISTANCE IN HUMANS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/134711
dc.description.abstractIn this thesis, perturbation in immune-metabolic function associated with obesity induced insulin resistance was investigated. First, the mediatory role of adipocytokines, as biomarkers of inflammation in the link between abdominal obesity and insulin resistance, was explored in a multi-ethnic cross-sectional cohort of Asian subjects. Second, postprandial immune-metabolic responses to meal with different composition were evaluated in obese insulin resistant compared to lean insulin sensitive subjects in a cross-over randomized trial. In summary, results of the studies presented in this thesis clarify the role of adipocytokines as mediators for association between abdominal obesity and insulin resistance in different Asian ethnic group. This thesis also describes that different macronutrients in the diet have differential effect on postprandial immune-metabolic responses, and such responses are perturbed in obese insulin resistant individuals as compared to lean insulin sensitive individuals.
dc.language.isoen
dc.subjectOBESITY, INSULIN RESISTANCE,IMMUNE-METABOLIC RESPONSE, ASIAN ETHNICITY, ADIPOCYTOKINES
dc.typeThesis
dc.contributor.departmentMEDICINE
dc.contributor.supervisorTAI E SHYONG
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PhD Thesis_Ehsan Parvaresh Rizi_A0098692J_Final Version.pdf4.19 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

24
checked on Jul 19, 2019

Download(s)

3
checked on Jul 19, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.