Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134680
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dc.titleA NOVEL FLOW SYSTEM UTILIZING AN EXPLANTED PORCINE HEART TO DETERMINE THE EFFICACY OF CAVAL VALVE IMPLANTATION
dc.contributor.authorKARTHIC ANBALAKAN
dc.date.accessioned2017-01-31T18:00:36Z
dc.date.available2017-01-31T18:00:36Z
dc.date.issued2016-08-18
dc.identifier.citationKARTHIC ANBALAKAN (2016-08-18). A NOVEL FLOW SYSTEM UTILIZING AN EXPLANTED PORCINE HEART TO DETERMINE THE EFFICACY OF CAVAL VALVE IMPLANTATION. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/134680
dc.description.abstractTricuspid regurgitation is one of the often neglected pathologies which can occur secondary to left sided heart disease. The current treatment methods are open surgical procedures which carry a high operative mortality. Therefore, TR is often left untreated in patients where the risks outweigh the benefits. To exacerbate this further, TR was found to be progressive and could potentially worsen significantly within 5 years. In this study, the efficacy of a new percutaneous transcatheter technique, known as Caval Valve Implantation (CAVI), was investigated; through the development of an in-vitro flow system which utilized an explanted porcine heart. From the results, the cardiac output was found to be 2.22 times greater after CAVI and the Jugular Venous Pressure waveform was restored. Moreover, 2D-pulse-wave-color Doppler echocardiography reflected a 2.42 fold decrease in the Effective-Regurgitant-Orifice-Area after CAVI. These results support the efficacy of CAVI and its potential to treat the symptoms of TR.
dc.language.isoen
dc.subjectTricuspid Valve, Regurgitation, Caval Valve Implantation, Heterotopic Implantation, Proximal Isovelocity Surface Area, In vitro Flow System
dc.typeThesis
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.supervisorLEO HWA LIANG
dc.description.degreeMaster's
dc.description.degreeconferredMASTER OF ENGINEERING
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Master's Theses (Open)

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