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Title: C-erBB2 over-expression in invasive breast carcinoma
Keywords: Invasive breast cancer; C-erbB2; Immunohistochemistry; FISH; Nuclear morphometry; Overall survival
Issue Date: 2-Dec-2003
Citation: SATHIYAMOORTHY SELVARAJAN (2003-12-02). C-erBB2 over-expression in invasive breast carcinoma. ScholarBank@NUS Repository.
Abstract: The c-erbB2 proto-oncogene, which belongs to the human epidermal growth factor receptor family, is known to be either amplified, overexpressed, or both in human malignancies. In this study, c-erbB2 gene amplification and protein expression was evaluated by Fluorescent in situ hybridization and immunohistochemistry in a series of Singapore women with invasive breast cancer and correlated with pathologic parameters. Salient findings include the observation of a positive correlation of c-erbB2 expression with histologic grade and a negative correlation with hormonal status. Patients with c-erB2-positive cancers had a poorer prognosis as disease free and overall survival was lower than their c-erB2-negative counterparts.
Appears in Collections:Master's Theses (Open)

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