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|Title:||THE ROLE OF COLONIC ANTIMICROBIAL PEPTIDES IN HUMAN BLASTOCYSTIS INFECTIONS||Authors:||JOHN ANTHONY D. YASON||Keywords:||Blastocystis, subtype, antimicrobial peptides, resistance, innate immune response||Issue Date:||18-Aug-2016||Citation:||JOHN ANTHONY D. YASON (2016-08-18). THE ROLE OF COLONIC ANTIMICROBIAL PEPTIDES IN HUMAN BLASTOCYSTIS INFECTIONS. ScholarBank@NUS Repository.||Abstract:||Blastocystis is a common eukaryotic organism found in the human gut. The study explores the roles of antimicrobial peptides (AMPs) expressed in the colon when Blastocystis infect humans. AMPs are elements of the innate immunity and contribute in the protection of the intestinal mucosa from microbial invasion. A drug assay was used to identify the susceptibility of Blastocystis to three colonic AMPs (cathelicidin/LL-37, human beta-defensin 1 and human beta-defensin 2). LL-37 was found to have broad activity on various Blastocystis isolates. However, Blastocystis subtype (ST) 7 isolates showed relative resistance against the peptide. This is due to the ST’s ability to secrete proteases and alter the surrounding pH. The thicker surface coat of ST7 isolates may also confer resistance against LL-37 killing. The parasite can induce LL-37 gene expression in intestinal cells. Results in this study suggest a significant role for AMPs, particularly LL-37, in human Blastocystis infections.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134570|
|Appears in Collections:||Ph.D Theses (Open)|
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