Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134413
DC FieldValue
dc.titleRHODIUM/PALLADIUM-CATALYZED ENANTIOSELECTIVE ADDITION REACTIONS
dc.contributor.authorZHOU BO
dc.date.accessioned2016-12-31T18:00:50Z
dc.date.available2016-12-31T18:00:50Z
dc.date.issued2016-08-16
dc.identifier.citationZHOU BO (2016-08-16). RHODIUM/PALLADIUM-CATALYZED ENANTIOSELECTIVE ADDITION REACTIONS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/134413
dc.description.abstractTransition metal-catalyzed carbon-carbon bonds formations are of great importance in organic synthesis. Especially, the rhodium/palladium-catalyzed asymmetric addition reactions have attracted great attentions because of their high efficiency, special selectivity and mild reaction conditions. In this thesis, newly designed C1 symmetric chiral dienes were employed to rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to enones. These simple synthesis C1 symmetric chiral dienes demonstrated higher catalytic activities and enantioselectivities in a wide substrate scope, compared with standard chiral dienes. In addition, amino acid derived phosphinooxazoline and phosphine-imine ligands were applied to the palladium-catalyzed asymmetric arylation reactions. The cationic palladium/phosphinooxazoline catalyst presented very high enantioselectivities in arylation of fluoroalkyl substituted 2-quinazolinone derivatives. Besides, the phosphine-imine ligands were for the first time applied to the palladium-catalyzed asymmetric arylation reactions, in which high catalytic activities, useful level of enantioselectivies, and wide scope were obtained.
dc.language.isoen
dc.subjectrhodium, palladium, asymmetric 1,4-addition, asymmetric arylation
dc.typeThesis
dc.contributor.departmentCHEMISTRY
dc.contributor.supervisorLU YIXIN
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ZhouB.pdf5.63 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.