Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/134394
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dc.titleNUMERICAL AND EXPERIMENTAL INVESTGIATION OF CRYO-FREEZING WITH LARGE BLOOD VESSELS
dc.contributor.authorGE MENGYI
dc.date.accessioned2016-12-31T18:00:23Z
dc.date.available2016-12-31T18:00:23Z
dc.date.issued2016-08-08
dc.identifier.citationGE MENGYI (2016-08-08). NUMERICAL AND EXPERIMENTAL INVESTGIATION OF CRYO-FREEZING WITH LARGE BLOOD VESSELS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/134394
dc.description.abstractCryosurgery is accepted as a favorable treatment option for eradicating undesirable cancerous tissue due to its minimally invasive nature. A finite difference study of a biological liver tissue undergoing cryo-freezing using the immersed boundary method (IBM) is presented in this study. The liver tissue is treated as a non-ideal material having temperature-dependent thermophysical properties. The influence of heating effect due to blood flow (through the vessel surface) has been investigated by applying the boundary condition-enforced IBM. Results have indicated that the heat source term due to the blood flow in the vessel embedded in the bioheat transfer equation significantly impacts the tissue temperature profiles and thermal gradient histories. The effects of the blood vessel structure and injected nanoparticles on the cryo-freezing of a clinically-extracted vascular tissue are numerically investigated. This improved cryo-freezing model is able to significantly simplify the mesh generation process at the boundary resulting in improved computational efficacy.
dc.language.isoen
dc.subjectcryosurgery, simulation, immersed boundary method, heat transfer, nanoparticle, liver cancer
dc.typeThesis
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.supervisorSHU CHANG
dc.contributor.supervisorCHUA KIAN JON, ERNEST
dc.contributor.supervisorYANG WENMING
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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