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|Title:||MULTI-SCALE MODELLING OF GASTROINTESTINAL SMOOTH MUSCLE ELECTRO-MECHANICS||Authors:||CHENG ZI YI, NICHOLAS||Keywords:||mathematical, modelling, gastrointestinal, smooth muscle, electro-mechanics, finite element method||Issue Date:||7-Jul-2016||Citation:||CHENG ZI YI, NICHOLAS (2016-07-07). MULTI-SCALE MODELLING OF GASTROINTESTINAL SMOOTH MUSCLE ELECTRO-MECHANICS. ScholarBank@NUS Repository.||Abstract:||In this thesis, a multi-scale computational framework to study gastrointestinal smooth muscle electro-mechanics in motility and transport was developed. Normal gastrointestinal (GI) motility, brought about by the coordinated contraction and relaxation of smooth muscle cells, is essential in health. Motility is the mixing and transport of ingested contents via smooth muscle contractions, and the contraction of a smooth muscle cell is underpinned by its electro-mechanics, being the interactions between the electrical activity of the cell and its mechanical behaviour. The electromechanical coupling within smooth muscles can be divided into two phenomena: excitation-contraction coupling, and mechano-electric feedback. This thesis attempts to model gastrointestinal electro-mechanics using a bottom-up approach. First, a biophysical description of the electro-mechanics of the smooth muscle cell was developed. Following this, a tissue-level framework was constructed by extending the principles from the cellular model, where applicable using continuum methods, resulting in a strongly coupled model of gastrointestinal electro-mechanics.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134371|
|Appears in Collections:||Ph.D Theses (Open)|
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