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|Title:||SERUM SEROTONIN IN COGNITIVE DECLINE, CEREBROVASCULAR DISEASE AND CEREBRAL ATROPHY||Authors:||THONG HWAI KIT||Keywords:||Serotonin, Cogntive Decline, Cerebrovascualar Disease, Cerebral Atophy, Dementia, CIND||Issue Date:||16-Aug-2016||Citation:||THONG HWAI KIT (2016-08-16). SERUM SEROTONIN IN COGNITIVE DECLINE, CEREBROVASCULAR DISEASE AND CEREBRAL ATROPHY. ScholarBank@NUS Repository.||Abstract:||We investigated baseline serotonin levels in the serum of dementia patients (cognitive impairment with no dementia (CIND) and non-cognitively impaired (NCI) subjects; and association of baseline serum serotonin levels with baseline brain atrophy, baseline cerebrovascular disease, and cognitive decline at 1 year follow up (measured by Mini-Mental State Examination) were investigated. We found that high baseline serum serotonin level was associated with higher risk of having MMSE drop ≥3 at 1 year follow up, in CIND subjects only. Similarly, in CIND subjects only, increase in the central atrophy grading was associated with higher risk of having MMSE drop ≥3 at 1 year follow up. High baseline serum serotonin level was also associated with higher risk of having presence of central atrophy and severe central atrophy at baseline. No significant association was found for presence of cerebrovascular disease at baseline with baseline serum serotonin and MMSE drop.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134354|
|Appears in Collections:||Master's Theses (Open)|
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