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Title: The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations
Authors: Hallman, D.M.
Boerwinkle, E.
Saha, N. 
Sandholzer, C.
Menzel, H.J.
Csázár, A.
Utermann, G.
Issue Date: Aug-1991
Citation: Hallman, D.M., Boerwinkle, E., Saha, N., Sandholzer, C., Menzel, H.J., Csázár, A., Utermann, G. (1991-08). The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations. American Journal of Human Genetics 49 (2) : 338-349. ScholarBank@NUS Repository.
Abstract: Application of uniform methods for measuring the apolipoprotein (apo) E polymorphism and plasma cholesterol levels in nine populations (Tyrolean, Sudanese, Indian, Chinese, Japanese, Hungarian, Icelandic, Finnish, and Malay) revealed significant heterogeneity among them in apo E type frequencies and mean cholesterol levels. The major apo E types in all populations were E3/2 (frequency range from 7.0% in Indians to 16.9% in Malays), E3/3 (frequency range from 39.8% in Sudanese to 72.1% in Japanese), and E3/4 (frequency range from 11.3% in Japanese to 35.9% in Sudanese). Mean cholesterol levels ranged from 144.2 mg/dl in the Sudanese to 228.5 mg/dl in the Icelandics. Two-way analysis of variance of the effect of population and apo E type on cholesterol levels showed no significant interaction effect, indicating that the effects of apo E type on cholesterol levels do not differ significantly among the populations. The overall average excess for the ε2 allele was -14.12 mg/dl (range -31.63 to -8.82 mg/dl); for the ε3 allele, 0.04 mg/dl (range -1.87 to 1.58 mg/dl; and for the ε4 allele, 8.14 mg/dl (range -1.71 to 13.31 mg/dl). Despite the apparent heterogeneity in these values, especially for the ε4 allele, comparison of the average excesses by a method of repeated sampling with random permutations revealed no significant difference in effects among populations. These data indicate that a given apo E allele acts in a relatively uniform manner in different populations despite differences in genetic background and environmental factors.
Source Title: American Journal of Human Genetics
ISSN: 00029297
Appears in Collections:Staff Publications

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