Please use this identifier to cite or link to this item:
|Title:||Stereoselective disposition of ibuprofen enantiomers in man||Authors:||Lee, E.J.D.
|Issue Date:||1985||Citation:||Lee, E.J.D., Williams, K., Day, R., Graham, G., Champion, D. (1985). Stereoselective disposition of ibuprofen enantiomers in man. British Journal of Clinical Pharmacology 19 (5) : 669-674. ScholarBank@NUS Repository.||Abstract:||This study has examined the stereoselective disposition of the enantiomers of ibuprofen in 4 healthy male subjects following separate administration of racemic ibuprofen (800 mg) and of each enantiomer (400 mg). A mean of 63 ± 6% of an administered dose of R(-) ibuprofen was stereospecifically inverted to the S(+) enantiomer. There was no measurable inversion of the S(+) to R(-) ibuprofen. The kinetics of the individual enantiomers were altered by concurrent administration of the respective optical antipode. It is likely that this change reflects an interaction between the enantiomers at plasma protein binding sites. It was found that formation of ester glucuronide conjugates stereoselectively favoured the S(+) enantiomer. The data have demonstrated that the pharmacokinetics of ibuprofen and other α-methylarylacetic acids cannot be interpreted adequately without studying the pharmacokinetics of the individual enantiomers.||Source Title:||British Journal of Clinical Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/133973||ISSN:||03065251|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 8, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.